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They studied 30 workers exposed to lead and a group of 27 unexposed controls

Scientific Reports DOI:10.1038/s41598-026-60835-w Abstract Enhanced HGF with increased receptor affinity and nitration-dysfunction resistance through interaction with lipoic acid trisulfide Myogenic stem cell activator HGF (hepatocyte growth factor) undergoes nitration of tyrosine residues (Y198, Y250) predominantly on fast-twitch fibers to lose its binding affinity to the signaling receptor c-met, in response to peroxynitrite (ONOO ) generation during aging

Conclusion FOXO4-DRI has drawn scientific attention for its potential use in investigating cellular senescence, transcription factor signaling, and age-related processes

Fujii T, Wada-Hiraike O, Nagamatsu T, Harada M, Hirata T, Koga K, et al

In the resting state, continuous IGF1 stimulation ultimately induced down-regulation of Akt or ERK and Foxo3a activation, thereby inhibiting proliferation and enhancing self-renewal