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2025: Novo Nordisk announced positive Phase 3 ESSENCE trial results for semaglutide in early Alzheimer's disease, reporting statistically significant slowing of cognitive and functional decline a breakthrough data package that could establish GLP-1 therapy as a neuroprotective agent and open an addressable market of 6.5 million Alzheimer's patients in the U.S
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doi: 10.3389/fneur.2022.844697 40 ZhangLQZhangWLiTYangTYuanXZhouYet al
Key mechanism: Inhibition of COX-1 and COX-2 enzymes Prostaglandin (PGE, PGI) synthesis Afferent arteriolar vasoconstriction Renal blood flow & GFR Sodium and water retention Blood volume Increased peripheral vascular resistance Elevated blood pressure Reduced renal perfusion Acute kidney injury (AKI) in susceptible individuals Patients at higher risk: Chronic kidney disease (CKD) Heart failure Hypertension Elderly patients Volume depletion or dehydration Concomitant use of ACE inhibitors/ARBs and diuretics (Triple Whammy) Clinical takeaway: NSAIDs should be prescribed with caution, especially in patients with cardiovascular or renal risk factors
Cells (4 10 6 ) were cultured in 75 cm 2 tissue culture flasks in control conditions and exposed either to 0.4 mM L-cysteine and/or 0.1 mM cobalt chloride for 16 h
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