(PubMed) Morris MC, Evans DA, Bienias JL, Tangney CC, Wilson RS
Rodent studies repeatedly report that Epitalon administration normalises age-related declines in nocturnal melatonin secretion and restores entrainment of circadian rhythms in old animals
Its about what you consistently do for your body
Combine berberine with lifestyle changes, like losing weight, and it can positively affect those conditions. Theres also evidence that berberine may: Berberine is good for your gut, but ironically, its most common side effects involve the digestive system and include: Not everyone experiences berberine side effects, which should become tolerable if you reduce your berberine dosage
If I had to guess, I would say it is a functionally inert string of amino acids with no real safety or efficacy signal at all