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The synergy protocol Here is what a complete weekly protocol looks like when combining semaglutide, creatine, and resistance training: Daily: 5 grams creatine monohydrate with your largest meal 1.6-2.2 grams protein per kg bodyweight, distributed across meals Minimum 3 liters water Semaglutide injection on your regular schedule 3-4 times per week: 30-45 minutes resistance training Focus on compound movements Track weights and reps to ensure progressive overload Take creatine within 2 hours post-workout on training days Weekly check-ins: Track body weight and waist circumference (not just scale weight) Note training performance (are weights going up or maintaining?) Assess energy levels and energy on semaglutide Evaluate GI tolerance of creatine Creatine and semaglutide side effects: what to watch for Most people tolerate the combination well

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With guidance from a healthcare provider or registered dietitian, some people use targeted nutritional supplements as part of this monitoring process