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Central & peripheral glucagon-like peptide-1 receptor signaling differentially regulate addictive behaviors
By July 2025, the FDA had received 1,150 side-effect reports linked to unapproved GLP-1 drugs, including 545 related to compounded versions of Mounjaro
Severe gastrointestinal disease, particularly gastroparesis, may be exacerbated by semaglutide due to its effects on gastric emptying
Those are the high-impact variables
The semaglutide Summary of Product Characteristics (SmPC) notes the diabetic retinopathy findings from SUSTAIN-6 and recommends appropriate monitoring for patients with diabetic retinopathy
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