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2 trial for systemic sclerosis, a rare autoimmune disease, but did not demonstrate efficacy at 120 mg PO QD despite biomarkers of on-target activity and has been deprioritized by Gesynta
Frequently Asked Questions Does berberine activate GLP-1 receptors, according to the article
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doi: 10.1016/j.bbrc.2011.06.004 170 HwangJ
This compound is studied extensively in animal models for its anti-obesity effects and potential to improve metabolic parameters such as insulin sensitivity 1-4
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