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Blonde L, Jendle J, Gross J, Woo V, Jiang H, Fahrbach JL, et al

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IGF-1 LR3 provides continuous, supraphysiological IGF-1 receptor stimulation that doesn't replicate natural growth hormone dynamics

In addition, for PCOS patients with insulin resistance (IR), metformin can effectively reduce hyperglycemia and hyperinsulinemia, improve ovulatory function, reduce androgen levels, control weight and waist circumference gain, and mitigate the risks of diabetes mellitus and cardiovascular disease (Notaro and Neto, 2022)