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DEVOTE landmark safety outcomes trial Tresiba U-100 demonstrated no increased risk of major adverse cardiovascular events (MACE) vs insulin glargine U-100 for adults with type 2 diabetes and ASCVD 2,d The secondary confirmatory endpoint showed Tresiba U-100 also demonstrated statistically significant lower rates of severe hypoglycemic events vs insulin glargine U-100 2,e A flat and stable profile 2-4 Tresiba provides a steady rate of absorption into the bloodstream, giving it a flat and stable profile at steady state
doi:10.1016/j.yjmcc.2015.09.018 84
Always follow dosing instructions and titrate slowly as advised by your doctor
However, their financial sustainability remains an open question as utilization continues to rise, placing substantial strain on employer-sponsored health plans
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