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This initial dose allows the body to adjust to GLP-1 receptor activation and minimizes the risk of severe gastrointestinal side effects

Table of Contents Mechanism of action of GLP-1 The emerging clinical research and drug marketing Wegovy and Ozempic, side-by-side Side effects and adverse events Current anesthesia care guidance on patient care Summary of where we are Mechanism of action of GLP-1 GLP-1 is a hormone inactivated by the enzyme DPP-4

Does not reliably increase systemic glutathione levels in healthy individuals because the tripeptide is rapidly broken down in the gut and bloodstream into its constituent amino acids (cysteine, glutamate, glycine)

New England Journal of Medicine 362, 906916 (2010)

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