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Research using MT-1 in cell systems expressing MC1R variants associated with red hair and fair skin has characterised reduced cAMP signalling responses, impaired MITF activation, and decreased melanogenesis , documenting the functional consequences of loss-of-function MC1R polymorphisms at the receptor signalling level and establishing the molecular basis for the reduced photoprotective melanogenesis capacity associated with these variants

The subtle balance between lipolysis and lipogenesis: a critical point in metabolic homeostasis

Second, the cardiomyocyte dysfunction in ob/ob mice is partially attributed to the lack of leptin signaling in cardiomyocytes, as administration of leptin to cardiomyocytes ex-vivo rescues their pro-apoptotic phenotype (Trivedi et al., 2008) and restores their contractility ( 2.3.3 db/db mice (H 2 FPEF score 5) The leptin receptor-deficient, or diabetic ( db/db ) mice harbor a point mutation in the leptin receptor gene, altering its sensitivity to leptin( db / db mice display insulin resistance at younger age compared to humans, the late-stage manifestation of insulin secretion defect well approximates the pathogenesis of type II diabetes in human, making db / db mice a valuable model in exploring the combined contribution of obesity and type II diabetes to HFpEF

Houten SM, Wanders RJA

Li D, Jiang Y, Cui Z, Ma M, Zhu F, Li G, Yang H, Li S, Zhang T, Chen D, Ma W (2024) Lactobacillus acidophilus protects against Corynebacterium pseudotuberculosis infection by regulating the autophagy of macrophages and maintaining gut microbiota homeostasis in C57BL/6 mice