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In humans, this effect is achieved by the administration of DPP-4 inhibitors, a type of antidiabetic agents that preserve the active form of incretins (Zhong et al., 2015)
doi: 10.3390/ijms141021021
Holst, 2007)
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Ceramide generation was a critical component of Fas receptor-induced eryptosis, whereas therapy with natural organosulfur compounds inhibited the apoptotic death of erythrocytes by antagonizing oxidative stress and the Gardos channel that led to suppression of ceramide-initiated Fas aggregation in lipid rafts of these erythrocytes
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