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The intranasal GHK-Cu treatment was found to delay cognitive impairment, reduce amyloid plaques, and lower inflammation levels in the frontal cortex and hippocampus .37 Randomized controlled trials in human patients are needed to confirm the benefit of GHK-Cu for cognitive decline and Alzheimers disease as well as to evaluate safe and effective human dosing (the human dose equivalent of 15mg/kg in mice would be ~1.2mg/kg, though data on this or any other dosing nasally in humans is not currently available), but preliminary animal trials are promising
Since mammalian mPGES-2s have a defined role in prostanoid metabolism, all studies primarily investigated the PGH 2 conversion into PGE 2 (Watanabe et al., 1997)
Regular exercise may help restore glutathione levels and improve antioxidant activities
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