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Materials and methods Human brain tissue and neuropathology The use of post-mortem brain tissues from the BRAIN cohort (Brain Research in Aging, Inflammation and Neurodegeneration) was evaluated by the METc (nr 2021/496) on August 31, 2021, concluding that the protocol is not clinical research with humans as meant in the Medical Research Involving Human Subjects Act
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In those patients, addressing the underlying metabolic dysfunction first, through dietary intervention, GLP-1 therapy if indicated, or NAD+ support for cellular energy metabolism, is the clinical priority
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