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[9] High-dose niacin (used to treat cholesterol) lacks human safety data in pregnancy and could theoretically affect the fetus (for example, by causing hypotension or altering lipid metabolism)

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Food and Drug Administration declined to comment on the lawsuit

STEP-5 extended the observation window to 104 weeks (N=304) and found mean weight loss of 15.2% with semaglutide 2.4 mg versus 2.6% placebo, demonstrating that the drug sustains its effect across two full years without clinically meaningful attenuation [10]

What To Watch For These symptoms occur as your body adjusts to the absence of the medications effects: Watch for increased hunger, weight regain, and unstable blood sugar levels after reducing or discontinuing tirzepatide