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[53] The results of folic acid fortification on the rate of neural tube defects in Canada have been positive, showing a 46% reduction in prevalence of NTDs

Whereas plain glutathione must be broken down by enzymes to the basic amino acid components for absorption into the cell requiring more energy expenditure to be re-constructed back to reduced glutathione (rGSH)

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It is a key supplement for people suffering from pernicious anemia, and for vegetarians and vegans that have vitamin B12 deficiencies related to dietary choices