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Tirzepatide is a novel glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (marketed as Mounjaro) and chronic weight management (marketed as Zepbound)

Exp Mol Med 53(9):13191331 Luo Y, Chen G-L, Hannemann N, Ipseiz N, Krnke G, Buerle T, Munos L, Wirtz S, Schett G, Bozec A (2015) Microbiota from obese mice regulate hematopoietic stem cell differentiation by altering the bone niche