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Treatment with GLP-1RAs can reduce monocyte/macrophage accumulation in the arterial wall by inhibiting the adhesion of monocytes to activated endothelium from the arteries of C57BL/6 mice as well as in ApoE -/- mice [64]
This does not automatically invalidate them, but it means they have not undergone the rigor that clinical trials for pharmaceutical GLP-1 compounds must pass
However, as their long-term benefits beyond weight loss become more widely recognized, broader coverage is expected
Different doses (5MG, 10MG, 15MG) are tested to evaluate how exposure levels influence pathway activity
placebo Average weight loss: 14.9% over 68 weeks (vs
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