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10.1007/s00702-014-1182-6 105
Expect surface adsorption losses at low concentration
In clinical use, children with extensive thermal burns who were treated with IGF-I in combination with IGFBP-3, presented a reduction in serum levels of IL-1, TNF-, C-reactive protein, 1-acid glycoprotein, and complement C-3[299]
Thus, preventing the interaction between FcRn and IgG was found to be attainable by the use of peptides, active competition by large amounts of IgG, mAbs, and fusion proteins containing Fabs specific for FcRn, Fc-engineered IgGs, and affibodies
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