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When combined with radiotherapy and PD-1 blockade, these nanoparticles promote CD8+ T cell infiltration and activate antitumor immune responses, demonstrating the potential of metal-based nanoplatforms to synergize with multiple therapeutic modalities (57) ( Figure 2 )

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This review includes the most relevant studies contributing to a better understanding of the intracellular pathways and molecular mechanisms triggered after GLP-1R stimulation in cardiomyocytes, with a particular focus on the modulation of the RISK pathway and the inhibition of cell death mechanisms