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The role of the ubiquitin proteasome system (UPS) in the heart The UPS as a central and highly selective proteostasis system in cardiomyocytes Alongside autophagy and mitophagy, the ubiquitinproteasome system (UPS) represents a central pillar of cardiac proteostasis, responsible for the highly selective degradation of damaged, misfolded, or regulatory proteins and thereby safeguarding cellular homeostasis and protein turnover (Fig

Angelini C, Trevisan C, Isaya G, Pegolo G, Vergani L: Clinical varieties of carnitine and carnitine palmitoyltransferase deficiency

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