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The upregulated TXNIP downregulates MafA and thus inhibits insulin expression in LOsG-treated -cell
No differences were observed in the expression of this GST between wild-type A
First, at the mechanistic level, single-cell spatial transcriptomics and metabolomics should be used to map ferroptosis pathways in nigral dopaminergic neurons, astrocytes, and microglia, with emphasis on the interplay between NCOA4-mediated ferritinophagy and -synuclein degradation, to build a dynamic model linking iron dysregulation, proteotoxic stress, and cell death
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