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mid-term goals (35 years) should include initiating first-in-human trials and developing companion diagnostics

Saxenda Daily oral GLP-1 medication: Rybelsus Non-GLP-1 medications: Metformin (an insulin sensitizer, often off-label for weight management) and combination naltrexone/bupropion (Contrave) Lifestyle and nutrition support: Personalized nutrition plans

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In type 2 diabetes, the incretin effect is reduced