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Risk assessments that identify hazards specific to peptide reconstitution (sharps, allergens, splash exposure)

Acetaminophen, in particular, is known to produce a toxic metabolite that is normally detoxified by glutathione

Crucially, this study shifted the scientific paradigm from a simple model of "glutathione depletion" to a model of an "overwhelmed compensatory mechanism." The discovery that circulating immune cells in these patients actually have elevated glutathione levelswhile simultaneously suffering from a severe depletion of other protective enzymes like SOD2revealed that the cells are desperately, and unsuccessfully, trying to fight off a catastrophic level of oxidative damage

PMCID: PMC8000371

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