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GLP-1 producing neurons in the brainstem are activated following a large satiating meal suggesting that these neurons relay satiety signals to higher brain regions (Kreisler et al., Glp1r/ animals are leaner than wild-type (WT) controls (Hansotia et al., Glp1r/ mice, animals with deletion of the GLP-1R in vagal afferent/efferent nerves, Phox2b-Cre Glp1r flox/flox , as well as animals with a deletion of the GLP-1R in the CNS, nestin- Cre Glp1r flox/flox , maintain a similar body weight and food intake as control mice on both chow and HFD (Sisley et al., Pharmacological effects of GLP-1R agonism on energy homeostasis Despite controversial findings over the role of the endogenous GLP-1 system in maintaining energy homeostasis, consistent findings demonstrate that pharmacological administration of GLP-1R agonists suppresses body weight across a number of species
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5 , 209ra151 (2013) J.P
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