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Cold sensitivity likely results from metabolic changes associated with weight loss, including reduced adipose tissue insulation, decreased basal metabolic rate, and adaptive thermogenesis from caloric restriction

The authors concluded that both drugs have a small incidence of cardiac dysautonomia as an adverse event, the majority of which was classified as non-serious, but called for more studies

Angina, or chest pain, has improved with L-carnitine supplements, exercise ability, and chest pain in those with cardiac syndrome X

Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes