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The ability of hydroxocobalamin to rapidly scavenge and detoxify cyanide by chelation has resulted in several acute animal and human studies using systemic hydroxocobalamin doses at suprapharmacological doses as high as 140 mg/kg to support its use as an intravenous (IV) treatment for cyanide exposure
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Tissue homogenate supernatant mixed with thiobarbituric acid was used to evaluate the malondialdehyde (MDA) content by measuring the absorbance at 532 nm
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