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In a randomized, single-blind, 24-week study, participants assigned to dual therapy of 2 mg weekly of the GLP-1 receptor agonist exenatide (Bydureon, AstraZeneca) and 10 mg daily of the SGLT2 inhibitor dapagliflozin (Farxiga, AstraZeneca) lost more weight than those taking either agent alone or those receiving dapagliflozin and metformin extended-release (Xigduo XL, AstraZeneca) or phentermine/topiramate extended-release (Qsymia, Vivus)
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Melanotan-2 is the historical, non-selective, pan-melanocortin cyclic precursor heptapeptide and remains unapproved, intended solely for in vitro research
To make an informed choice, its important to look at the data
No withdrawal symptoms occur, but patients often notice decreased energy and sleep quality within weeks of discontinuation
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