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Why the Manufacturing Route Is Recombinant, Not Synthetic Solid-phase peptide synthesis (SPPS), the dominant route for research-grade peptides since Merrifield's 1963 demonstration of the method [3], becomes progressively inefficient as chain length grows: small yield losses at each coupling step compound across many residues, and full-length recovery falls
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Over days and weeks, these fluctuations stress the peptide structure and can reduce potency faster than the BUD anticipates
Goodpaster BH, Park SW, Harris TB, et al
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