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7) The Debtors seek approval of procedures restricting transfers of equity to preserve tax attributes approximately $660.6 million of federal net operating losses and approximately $62.2 million of section 163(j) interest carryforwards as of December 31, 2025, plus attributes generated since which could otherwise be limited under section 382 if an ownership change occurs

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445 participants with obesity and knee osteoarthritis, without diabetes, randomized 1:1:1 to 9mg, 12mg, or placebo over 68 weeks

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For instance, administering IGF-1R mAbs in cancer trials was reported to result in increased adverse events in younger populations 34 , including insulin resistance, possibly due in part to disruption of the somatotropic axis and associated deleterious effects of excess GH 41,42