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Statistical analyses followed the intention-to-treat principle

The metabolic benefits of fat mass reduction, including improved insulin sensitivity and cardiovascular risk profile, generally outweigh concerns about proportional lean mass loss in patients with obesity

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X-ray crystallographic studies have demonstrated that copper coordination occurs through the N-terminal amino group of glycine, the deprotonated peptide nitrogen of the Gly-His bond, and the imidazole nitrogen of histidine, forming a square-planar geometry characteristic of Cu(II) complexes

this enhances their absorption significantly