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Clinicians should systematically evaluate these potential causes when patients report persistent fatigue during GLP-1 therapy, as many are modifiable through dietary counseling, hydration strategies, or medication adjustment

This is particularly relevant because bupropion carries an FDA boxed warning regarding seizure risk, and seizure threshold is lowered by several modifiable factors: abrupt alcohol or benzodiazepine discontinuation, eating disorders (anorexia nervosa, bulimia), electrolyte abnormalities, and conditions that cause metabolic disruption [2]

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Each group had a mean starting body weight of 10.0 0.4 kg (mean SEM) and an average percent body fat of 28.8 0.14%

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