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They showed better effects in improving mouse motor function scores, promoting the repair and regeneration of synapses or dopaminergic neurons (TH+, GDNF, synaptophysin), and inhibiting neuroinflammatory responses (IBA-1, IL-2) compared to liraglutide and DA-JC1, highlighting the advantage of targeting more sites

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For individuals with IBS-C (constipation-predominant), Wegovy's tendency to slow gastric emptying and intestinal transit could theoretically worsen constipation

Nevertheless, translating these laboratory findings to clinical joint pain relief in humans requires further investigation