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In a pilot trial in patients awaiting gastrointestinal endoscopy or colorectal cancer resection, the administration of a mixture of three major curcuminoids (2.35 g/day for 14 days) resulted in detectable amounts of curcumin in colonic mucosa (mean concentration, 48.4 g/g of tissue), demethoxycurcumin (7.1 g/g), and bisdemethoxycurcumin (0.7 g/g) (78)

Expert opinion on investigational drugs, 2023, 32(5): 355-359

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Handling and Stability After First Use Once you begin using your compounded semaglutide pen or vial, the medication may be kept at room temperature (up to 86F or 30C) for up to 28 days, provided the pen remains unopened between uses