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Ricardo Correa, MD, EdD, the director of the University of Arizona endocrinology fellowship, told MedPage Today in 2022 that compounders are probably using the same active pharmacological part [semaglutide], but when you combine things and you add different excipients, the effectiveness if you dont measure that in a randomized controlled trial will not be the same. He added that not knowing exactly what the formulation contains makes prescribing too risky for him and the patient: Youre treating 100 patients and all of them have been doing fine with a compound medication you recommend

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Semaglutide is given once per week on the same day each week as a subcutaneous (under the skin) injection