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It has been proposed that positive TPO-Ab may result in cross-reaction with other tissues, as activated TPO-Ab-producing lymphocytes may leave the thyroid gland and invade other distant tissue, contributing to extrathyroidal symptoms and inflammation 18,19
PMID: 130 ZhangYChenYSunCLiFShenY
This process ultimately ensures the slight reduction of the Pelo-Hbs1 complex during viral infection
Modifications such as the substitution of tyrosine at the N-terminus appear to improve its stability compared to the native sequence
This was a statistically significant difference (p = 0.03)
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