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The combination group had the best effect, with cartilage close to normal

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Collectively, all these results above demonstrated that the introduction of MET could achieve dual enhancement of starvation therapy and chemodynamic therapy, proving the as-prepared GCMMR NPs is of great potential for cascade-enhanced therapeutic efficiency against hypoxic tumor

Resolutions must be found to the main issues associated with the clinical development of nanomedicines compared to current treatments, including biocompatibility and safety, large-scale manufacturing, and overall cost effectiveness [180]

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