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It has been hypothesized that the effects of GLP-1R agonists to reduce energy intake are at least partially driven by nausea and other GI AEs
Semaglutide at the 2.4mg weekly dose produced 13.7 percent body weight loss at 72 weeks in the STEP 1 trial
B% 43.18)
Those who shouldnt take GLP-1 agonists include people who: are pregnant, nursing, or planning to become pregnant have a history of thyroid cancer or pancreatitis are allergic or sensitive to any of the GLP-1 medications have multiple endocrine neoplasia (MEN) syndrome type 2 Weight loss medications are not recommended for people with past or active eating disorders
& DAlessio, D
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