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TMAO can change the bile acid spectrum to accelerate the formation of aortic lesions in ApoE / mice, and further activate the nuclear receptors farnesoid-X-receptor (FXR) and small heterodimer partner (SHP), to reduce the expression of cholesterol 7-hydroxylase (Cyp7a1) to inhibit bile acid synthesis, thus accelerating the formation of atherosclerosis (82)
J Rheumatol
Other inducers of erythrocyte death and concomitant ATP depletion include metals such as chromium [184], metalloids such as arsenic [185], riboflavin and UV light during RBC storage [186], and the phospholipid signaling molecule lysophosphatidic acid [187]
Researchers are thus well-advised to source injectable L-glutathione only from reputable sources, since there is always the risk of adverse effects linked to administering a contaminated product
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