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Galloway, S
344,505 The IFN-Is and cytokines triggered by TLRs trigger inflammation, creating a positive feedback loop that exacerbates autoimmune disease progression
Subramaniam SR, Chesselet MF (2013) Mitochondrial dysfunction and oxidative stress in Parkinsons disease
Glutathione peroxidase-4
This structural damage causes further mitochondrial failure and even more ROS leakage, creating a continuous "doom loop" of profound energy depletion, systemic inflammation, and the hallmark symptom of post-exertional malaise (PEM)
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