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Some possible explanations for the contradictory finding include the small sample sizes of the studies, the lack of multicenter or large-sample size studies to verify the reproducibility and generalizability of the results, and the effect of discontinuation conditions and depression itself on the validation of the conclusions of the Chengdu-based study (Figure 1)

These established timeframes provide guidance for realistic expectations of results timelines

SGLT-2=sodium-glucose co-transporter-2

Tirzepatide produces average weight loss of approximately 20% to 22.5% at its highest approved dose of 15 mg over 72 weeks

placebo in children and adolescents