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Dichloroacetate Dichloroacetate (DCA), a product of water chlorination, is considered for the treatment of several disorders including genetic mitochondrial diseases and some hyperproliferative conditions 82
[1] [3] The active ingredient, ascorbic acid, is a water-soluble vitamin essential for numerous physiological functions, including collagen synthesis, antioxidant defense, and immune support
& Topu, E
The redox cycling enzymes thioredoxin, thioredoxin reductase, sulfiredoxin, peroxiredoxin, GSH peroxidase, superoxide dismutase 1, and catalase, and several GSH S-transferases, which are the enzymes mediating the elimination of ROS, are all Nrf2 targets (242)
The completion of this fundamental adaptation can take weeks of constant exposure to novel situations, yet the temporal evolution of this adaptation is not instantaneous (6668)
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