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While not a substitute for medical evaluation, this data can inform decisions about continued use
SCFA metabolites, such as acetate, propionate, and butyrate, can act on fatty acid receptors in epithelial, enteroendocrine, and neuronal cells, and they could affect the central nervous system in experimental model organisms (53, 54)
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Therefore, when semaglutide is used for weight management, administer with caution in patients with depression and avoid use in patients with a history of suicide attempts or active suicidal ideation