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On one hand, targeted induction of ferroptosis presents a powerful strategy to eliminate tumor cells, particularly those resistant to apoptosis, and can synergize with standard chemotherapeutics like gemcitabine to overcome treatment resistance
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DALYs quantify overall disease burden by summing years of life lost due to premature death (YLLs) and years lived with disability (YLDs)
Modular DNA nanodevice agonists (DNDA) achieve selective uptake by macrophages through precise self-assembly, releasing cGAS-recognizing fragments intracellularly to activate the cGASSTING pathway, thereby synergizing with immune checkpoint blockade to exert antitumor effects (280)
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