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In the last two decades, compounding found new life with the boom in testosterone for men, hormone-replacement therapy for women, and, more recently, GLP-1 weight-loss drugs

The drug reduces hepatic glucose production, enhances glucose uptake in the peripheral tissues and increases insulin sensitivity 115

These changes lead to many consequences such as, inhibition of enzyme activity, binding activity, aggregation, proteolysis, increased or decreased cell uptake, altered immunogenicity

Exposure to ultraviolet light, like sunlight and tanning beds, is thought to contribute to age spots

However, if they continue to refuse, the editors could also fully retract the paper