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Generating an adaptive immune response requires naive B cells, which are the progenitors of effector and memory B cells
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Ladson G, Dodson WC, Sweet SD et al (2011) Effects of Metformin in adolescents with polycystic ovary syndrome undertaking lifestyle therapy: a pilot randomized double-blind study
This approach works best for patients who experience significant side effects on full-strength weekly dosing or prefer a gentler initiation
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