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26,34,35 In parallel, TCP, defined as the ability of cancer cells to reversibly adopt alternative phenotypic states, including EMT, lineage transdifferentiation, and acquisition of stem-like features, confers phenotypic flexibility that enables drug tolerance
The search terms used were obesity, OSA, ASP, EDS, CPAP, glucagon-like peptide-1 (GLP-1), GLP-1 receptor (GLP-1R) agonists, liraglutide (LIRA), exenatide (EXE), semaglutide (SEMA), dulaglutide (DULA), sodium-glucose co-transporters 2 (SGLT2) inhibitors, empagliflozin (EMPA), dapagliflozin (DAPA), ertugliflozin (ERTU), canagliflozin (CANA), and luseogliflozin (LUSEO)
The GIP receptor activation adds another layer
This occurs by metabolising various types of energy-providing substrates that are taken up from the blood circulation, and by changing the efficiency of utilization of different substrates as an adaptive response to altered physiological or metabolic environment 26
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