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Randomized controlled trials (RCTs) have shown that, compared to BI, GLP-1RA granted similar or greater HbA1c reductions, but with lower rates of hypoglycemia, substantial weight loss, and easier administration schedule [4]
Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes
Clinical trials of 48 weeks duration showed acceptable safety profiles
It impacts safety: Tolerance levels vary based on species, weight, and injury severity
Studies with longer follow-up duration are required to further investigate the potential factors associated with weight change after discontinuation of treatment
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