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Contact your GP or trial clinician promptly if you notice: A persistent increase in resting heart rate without an obvious cause Mild but recurrent palpitations or an awareness of your heartbeat Unexplained fatigue or reduced exercise tolerance New or worsening breathlessness during everyday activities It is worth noting that some degree of heart rate elevation may be an expected pharmacological effect of retatrutide, as discussed above

Patients should contact their GP or diabetes specialist nurse if diarrhoea is severe, persistent (lasting more than a few days), or significantly affecting their daily activities and quality of life

Bring your current dosage, recent lab work, and treatment history to your DrWell consultation

This review examines the link between diabetes and neurodegenerative diseases, explores the effects of antidiabetic agents on neurodegeneration, provides a concise overview of the GLP-1 pathway, and discusses both preclinical and clinical trial outcomes of GLP-1RAs for neurodegenerative diseases, including their effects on cognition in AD and PD