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Ongoing & Future Research Cardiovascular Outcomes Trial Status: Planning Phase Focus: Major adverse cardiovascular events (MACE) reduction with CagriSema in high-risk population Population: Adults with established CVD and obesity Timeline: Expected initiation 2024-2025

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In contrast, p21 enforces cell cycle checkpoints by inhibiting cyclin-dependent kinase (Cdk) complexes, blocking the G1-to-S phase transition and executing p53-dependent growth arrest ( Figure 2 ) (41, 42)