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All of these factors can contribute to poor production of glutathione (or of the enzymes that help glutathione to do its work), and many also deplete the GSH that the cells produce (by converting it into GSSG)

Changes in IgE, HLA-DR and Glutathione Antioxidant Pathway Components in Blood from Asthma Patients Treated with Ozone Therapy Abstract We have studied the relationship and behavior of serum imunoglobulin E (IgE) level, peripheral mononuclear cell human leukocyte antigen DR (HLA-DR) expression and erythrocyte glutathione antioxidant pathway in a group of patients suffering reactive asthma